OEM versions sometimes have vender-specific drivers that may not be normally included with a standard Windows CD.

Venders such as Compaq, Dell, etc., get bulk licensing for OEM distribution of Windows with their servers and workstations, which are usually offered to the end user at reduced prices versus purchasing a full retail version - and because of this, the licensing on OEM software generally is much more restrictive than the retail versions.

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Experience: Something you don't get until 10 minutes after you needed it.