Thanks to all for the input. I use a top of the line MOTU interface and the Kemper Guitar Profiler Rack version so I don't care about integrated audio. This will be the third machine I've built, the previous two were Asus ROG STRIX boards but I'm beginning to wonder how good they are, the last one only lasted 3 years. I've also been doing it for decades and I'm a pretty intense user, maybe 10 hours a day.

I also have heat dust and moisture in the environment because I live in the Mexican desert. I didn't get water cooling last time because i was told you could hear the pump running but I might get it this time.