I ran dual monitors for a few years and have been running three monitors for about 6 years and the display settings have always done it for me. As SuperSparks says there is that one minor irritation on opening some programs but it's not that often and you just simply move it over. You're gonna love it.
Biostar TA790GX A2+ 6.0
AMD Phenom X4 9750 CPU.
4 Gig DDR2 Memory.
ATI HD 5450 PCIe Video
ATI HD 5450 PCIe Video
500 Watt P.S.
LG W2241T Widescreen 22" LCD
ViewSonic VA721 17" LCD
Envision 17" LCD
2 LG DVD Drives
Floppy Disk Drive
Maxtor 120 Gig Windows 7 Home Premium 32 bit
Gateway NV5378-U Windows 7 Home Premium 64 bit
Acer Aspire V3-731 Windows 7 Home Premium 64 bit