The setting in Internet Explorer (actually a Control Panel setting) is used to specify a default e-mail program to use when an e-mail address link is clicked on. There are a variety of possible causes for Outlook e-mail not being sent. You need to make sure that Outlook is set to send the mail automatically instead of requiring someone to click on the Send/Receive button. Outlook also needs to be running for the Send to happen. And, if you have Norton or some other antivirus software that checks outgoing e-mail, that may be causing a problem. Some possibly useful links are below:

http://office.microsoft.com/en-us/ou...164681033.aspx

http://office-outlook.com/outlook-fo...964/#msg_87964

http://portal.gci.net/support/kb/kb79

http://forums.techguy.org/business-a...they-stay.html