I prefer GeekUninstaller, but you can also use Revo.

https://www.geekuninstaller.com/
http://www.revouninstaller.com/

TFC should take care of a lot, but you can also run CCleaner.
https://www.piriform.com/ccleaner

For defragging, I use Defraggler.
https://www.piriform.com/defraggler