Reg cleaners, I would not use them on my worst enemies computer.

As for the older machines, network them is what I do. And transfer through the lan.

You can remove the hdds and place them into a USB enclosure if you wish.

Lots of examples here.
http://www.newegg.com/Store/SubCateg...nal-Enclosures

Of coarse there are external hdds and some have backup programs, which I have never used.
http://www.newegg.com/Store/SubCateg...al-Hard-Drives

This may seem like overkill, but it one of the ones I use.
http://www.newegg.com/Product/Produc...82E16822148406